| Biography | |
|---|---|
 Prof. Zhen Yuan Faculty of Health Sciences, University of Macau, China |
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| Title: Temperature-feedback Nanoplatform for NIR-II Penta-modal Imaging-guided Synergistic Photothermal Therapy and CAR-NK immunotherapy of Lung Cancer | |
| Abstract: In this study, to visually acquire all-round structural and functional information of lung tumor while performing synergistic photothermal therapy (PTT) and targeting immunotherapy, a theranostic nanoplatform that introduced upconversion nanoparticles (UCNPs) and IR-1048 dye into the lipid-aptamer nanostructrure (UCILA) was constructed. Interestingly, the IR-1048 dye grafted into the lipid bilayer can serve as the theranostic agent for photoacoustic imaging, optical coherence tomography angiography, photothermal imaging and PTT in the second near infrared (NIR) window. In addition, loaded in the inner part of UCILA, UCNPs possess the superior luminescence property and high X-ray attenuation coefficient, which can act as contrast agents for CT and thermo-sensitive up-conversion luminescence (UCL) imaging, enabling real-time tracking of metabolic activity of tumor and temperature-feedback PTT. Further, under the complementary guidance of penta-modal imaging and an accurate control of in-situ temperature change during PTT, UCILA exhibited its excellent capability for ablating the lung tumor with minimal side effects. Meanwhile, synergistic CAR-NK immunotherapy was carried out specifically to eradicate any possible residual tumor cells after PTT. Therefore, the UCILA nanoplatform was demonstrated as a multifunctional theranostic agent for both penta-modal imaging and temperature-feedback PTT while conducting targeting immunotherapy of lung tumor. | |
| Biography: Dr. Yuan is an associate professor with the Faculty of Health Sciences at University of Macau (UM). Before joined UM, he had worked as an assistant professor with the Arizona State University and research assistant professor in Biomedical Engineering Dept. with the University of Florida. He got his PhD in Mechanical Engineering from the University of Science and Technology of China in 2002 and then finished his postdoc training in National University of Singapore, Clemson University and University of Florida between 2002 and 2007. His academic investigation is focused on cutting-edge research and development in laser, ultrasound and EEG/fMRI-related biomedical technologies as well as their clinical/pre-clinical applications in neuroimaging and neurosciences, and optical molecular imaging and cancer. He has achieved national and international recognition through more than 200 SCI publications in high ranked journals in his field. He is the editorial board member of Quantitative Imaging in Medicine and Surgery, associate editor of BMC Medical Imaging, and associate editor of Frontiers in Human Neuroscience. He is a senior member of OSA and senior member of SPIE. | |
