| Biography | |
|---|---|
 Prof. Min Yue Zhejiang University, China |
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| Title: Salmonella Goldcoast: an emerging threat to the global public health | |
| Abstract: The pathogenic etiologies are constantly changing in the dynamic world through time and place, posing an ongoing public health threat. Updated global pathogen surveillance is essential to address these public health threat, including caused by international disseminated Salmonella Goldcoast (SG). By conducting genomic and laboratory investigation, we observed a significant expansion and multi-drug resistance accumulation of SG in China, particularly in coastal regions. The global phylogenomic analysis of available 304 genomes identified four lineages, with three lineages (L-I, L-III, L-IV) resistant to quinolones and β-lactams, the two first-line antibiotics. Importantly, these three lineages were geographical related, but shared distinct antimicrobial-resistant gene and plasmid profiles. The BEAST analysis suggested SG isolates circulation in animal (L-I) and human (L-II, L-III, and L-IV) were separated by an independent evolution history, but with the same possible origin from European countries. Significant numbers of asymptomatic carriers were detected in mainland China, mainly in L-IV lineage. This study demonstrated distinct pathways in antimicrobial resistance acquisition for three epidemic clones and highlighted an asymptomatic population in China, and provided a framework for the integration of local epidemic isolates with global contextual datasets to improve prevision public health interventions via targeting asymptomatic population and regional rational antimicrobial therapy. | |
| Biography: Professional Experience Dec. 2019- present, Vice Chair of Department of Veterinary Medicine, ZJU Jul. 2016 - present, Principal Investigator, ZJU College of Animal Sciences. Aug. 2014 - Jul.2016, Research Associate, University of Pennsylvania. Aug. 2010 - Jul. 2014, Postdoc Fellow, School of Veterinary Medicine & Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (advisor: Prof. Dieter M. Schifferli) | |
