| Biography | |
|---|---|
 Prof. Min Yue Zhejiang University, China |
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| Title: Salmonella genomic epidemiology: new defending approach for global public health. | |
| Abstract: Genomic sequencing and corresponding big-data analytic toolkits are beginning to make a significant impact on food safety by providing a more precise platform for pathogen characterization, tracking, and streamline therapeutical treatment suggestions. Here, we focus on an emerging multi-drug resistance clone ST45 in Salmonella in China and many other countries. By using the 1800 genomics data from local sequenced strains and global datasets, with a well-characterized meta-data, we use the core SNPs from these datasets to build a global galaxy server for pathogen tracking and found it is efficient for tracking the origin and other phenotypical results in the context of the global food supply chain. Interestingly, We also found most of the multi-drug resistant strains showed a significant association with domesticated animals, mainly bovine, which was indicated as a probable reservoir for the multi-drug-resistant clone. We also use Random Forest, a machine learning toolkits, to prioritize the SNPs to associate with the antimicrobial resistance patterns in all the 1800 strains, and develop a molecular qPCR test, using the eight SNP markers, to predict the antimicrobial resistance pattern based on the newly established genotypes. This approach could be used to guide the risk assessments for the biohazard, i.e. Salmonella, along the food transmission chain and ultimately provide rational antimicrobial options for the clinicians. Together, our big-data platform provides an efficient way for Salmonella tracking and antimicrobial resistance pattern forecasting. | |
| Biography: Professional Experience Dec. 2019- present, Vice Chair of Department of Veterinary Medicine, ZJU Jul. 2016 - present, Principal Investigator, ZJU College of Animal Sciences. Aug. 2014 - Jul.2016, Research Associate, University of Pennsylvania. Aug. 2010 - Jul. 2014, Postdoc Fellow, School of Veterinary Medicine & Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (advisor: Prof. Dieter M. Schifferli) | |
