| 个人简介 | |
|---|---|
 Prof. Peng Zou College of Chemistry, Peking University, China |
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| 标题： Chemistry-enabled tools for neuroscience | |
| 摘要： Neural functions arise through the complex interactions between biological macromolecules, physical forces, and chemical signaling. My research group aims to develop enabling technologies to study cells at these three levels at high spatio-temporal resolutions. In this talk, I will present our recent work on a novel chemical biology approach to label RNAs in live cells. Our method, called CAP-seq, capitalizes on light-activated, proximity-dependent RNA oxidation. The high spatial resolution and high sensitivity of CAP-seq enabled us to profile the local transcriptomes near the endoplasmic reticulum and the mitochondria. I will also present our newly developed far-red hybrid voltage indicators, which allow us to optically track neuronal population-level action potential spike trains over 10 minutes, with submicron and millisecond resolutions. | |
| 简介： Dr. Zou received his Bachelor’s degree in Chemistry, with a double major in Physics from Peking University (PKU) in 2007, and his PhD in Biological Chemistry from MIT in 2012. Following his postdoc training with Dr. Adam Cohen at Harvard University, Dr. Zou joined PKU as an Assistant Professor in the College of Chemistry and Molecular Engineering in 2015. He was also appointed as a Principal Investigator at the PKU-IDG/McGovern Institute for Brain Research and the PKU-Tsinghua Center for Life Sciences. His lab focuses on inventing chemistry-enabled tools to study cellular structure, function and signaling pathways, with a particular focus on neuroscience. This mainly follows two lines of efforts: enzyme-based probes for profiling biomolecules in neurons, and optical reporters for neural activity. Dr. Zou is the recipient of the Thousand Young Talents Award in 2016, and has been selected for the Talented 12 award by ACS Chemical & Engineering News in 2019. | |
